Serum Leptin Levels in Relation to Quantitative Ultrasound Values of Calcaneus in Korean Postmenopausal Women in Chung-Up District / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 79-86, 2002.
Article
in Korean
| WPRIM
| ID: wpr-116764
ABSTRACT
BACKGROUND:
Obese postmenopausal women usually have a tend to have greater bone mineral density than lean women. This has been attributed to either the mechanical effects of their excessive weight on bone tissue or to their high body fat content. A recent study demonstrated that leptin, the hormone produced in adipocytes, acts on bone metabolism. These findings have prompted speculations on the possible role of leptin in the protective effect of obesity on bone. METHEODS We studied the relationship between serum leptin levels and quantitative ultrasound (QUS) values of calcaneus in 94 postmenopausal Korean women who were randomly selected from the population of the Chung-Up osteoporosis prevalence study. QUS values, broadband ultrasound attenuation and speed of sound; were measured at the calcaneus.RESULTS:
Leptin values were strongly correlated with body mass index (r = 0.478, p< 0.001), confirming a positive relationship between leptin levels and fat mass. In contrast, no significant correlations were observed between serum leptin levels and calcaneal QUS values.CONCLUSION:
Our results suggest that circulating plasma leptin does not have a significant influence on QUS values of calcaneus in Korean postmenopausal women.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Plasma
/
Bone and Bones
/
Calcaneus
/
Body Mass Index
/
Bone Density
/
Adipose Tissue
/
Cross-Sectional Studies
/
Ultrasonography
/
Adipocytes
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
Language:
Korean
Journal:
Journal of Korean Society of Endocrinology
Year:
2002
Type:
Article
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