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Fetal Nuchal Translucency Measurement for Detection of Chromosomal Abnormalities in the First Trimester of High Risk Pregnancy / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 2739-2742, 1998.
Article in Korean | WPRIM | ID: wpr-116993
ABSTRACT

OBJECTIVE:

To determine the value of sonographic nuchal translucency measurement for the detection of chromosomal abnormalities in high risk pregnancies.

METHOD:

The feasibility of nuchal translucency was tested in a prospective study of 1260 pregnancies at 10- 13 weeks' gestation.

RESULTS:

The nuchal translucency of 3 mm or greater was identified in 41 fetuses (3.2%), 19 of whom proved subsequently by either amniocentesis or postnatal follow-up have chromosomal abnormalities. The sensitivity of nuchal translucency for chromosomal abnormalities was 82.6% (19 of 23 cases), the positive predictive value of nuchal translucency for chromosomal abnormalities detection was 46.3% (19 of 41 cases).

CONCLUSION:

The observed sensitivity, false-positive rate and predictive value suggest that sonographic nuchal translucency should be undertaken at 10 to 13 weeks of gestation.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pregnancy Trimester, First / Prospective Studies / Follow-Up Studies / Chromosome Aberrations / Ultrasonography / Pregnancy, High-Risk / Nuchal Translucency Measurement / Fetus / Amniocentesis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 1998 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pregnancy Trimester, First / Prospective Studies / Follow-Up Studies / Chromosome Aberrations / Ultrasonography / Pregnancy, High-Risk / Nuchal Translucency Measurement / Fetus / Amniocentesis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Female / Humans / Pregnancy Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 1998 Type: Article