Sulfasalazine-induced Megaloblastic Anemia in Normal Serum Folate Level / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 231-234, 2005.
Article
in Korean
| WPRIM
| ID: wpr-117064
ABSTRACT
Sulfasalazine produces a varied spectrum of adverse reactions on the hematopoietic system. Sulfasalazine-induced megaloblastic anemia is very rare and a few cases have been reported in patients with inflammatory bowel disease. Most of them show a low serum folate level. The pathogenesis is known as folate deficiency by intestinal folate malabsorption, inhibition of folate enzyme, or hemolysis. We experienced a 43-year old female with Behcet's disease, who presented with megaloblastic anemia having normal serum folate level after treatement of sulfasalazine (2 g/day for 3 months). Megaloblastic anemia recovered after withdrawal of the drug only.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sulfasalazine
/
Inflammatory Bowel Diseases
/
Folic Acid
/
Hematopoietic System
/
Hemolysis
/
Anemia, Megaloblastic
/
Megaloblasts
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS