Recent Advances in Autoimmune Thyroid Diseases
Endocrinology and Metabolism
;
: 379-385, 2016.
Article
in English
| WPRIM
| ID: wpr-117327
ABSTRACT
Autoimmune thyroid disease (AITD) includes hyperthyroid Graves disease, hypothyroid autoimmune thyroiditis, and subtle subclinical thyroid dysfunctions. AITD is caused by interactions between genetic and environmental predisposing factors and results in autoimmune deterioration. Data on polymorphisms in the AITD susceptibility genes, related environmental factors, and dysregulation of autoimmune processes have accumulated over time. Over the last decade, there has been progress in the clinical field of AITD with respect to the available diagnostic and therapeutic methods as well as clinical consensus. The updated clinical guidelines allow practitioners to identify the most reasonable and current approaches for proper management. In this review, we focus on recent advances in understanding the genetic and environmental pathogenic mechanisms underlying AITD and introduce the updated set of clinical guidelines for AITD management. We also discuss other aspects of the disease such as management of subclinical thyroid dysfunction, use of levothyroxine plus levotriiodothyronine in the treatment of autoimmune hypothyroidism, risk assessment of long-standing antithyroid drug therapy in recurrent Graves' hyperthyroidism, and future research needs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Diseases
/
Thyroid Gland
/
Thyroxine
/
Thyroiditis, Autoimmune
/
Graves Disease
/
Causality
/
Risk Assessment
/
Genes, rel
/
Consensus
/
Drug Therapy
Type of study:
Etiology study
/
Practice guideline
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2016
Type:
Article
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