Relative biological effectiveness of fast neutrons for apoptosis in mouse hair follicles
Journal of Veterinary Science
;
: 335-340, 2007.
Article
in English
| WPRIM
| ID: wpr-117485
ABSTRACT
This study compared the effects of high linear energy transfer (LET) fast neutrons on the induction of apoptosis in the hair follicles of ICR mice with those of low LET (60)Co gamma-rays. The changes that occurred from 0 to 24 h after exposing the mice to either 2 Gy of gamma-rays (2 Gy/min) or 0.8 Gy of neutrons (94 mGy/min, 35 MeV) were examined. The maximum frequency was found at 12 h (gamma-rays) or 8 h (neutrons) after irradiation. The mice that received 0-8 Gy of gamma-rays or 0-1.6 Gy of neutrons were examined 8 h after irradiation. The dose-response curves were analyzed using the best-fit curve model. The dose-response curves were linear-quadratic, and a significant relationship was found between the frequency of apoptotic cells and the dose. The morphological findings in the irradiated groups were typical apoptotic fragments in the matrix region of the hair follicle, but the spontaneous existence of apoptotic fragments was rarely observed in the control group. In the presence of an apoptosis frequency between 2 and 14 per follicle, the relative biological effectiveness values of neutrons in small and large follicles were 2.09 +/- 0.30 and 2.15 +/- 0.18, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Apoptosis
/
Linear Energy Transfer
/
Hair Follicle
/
Dose-Response Relationship, Radiation
/
Fast Neutrons
/
Gamma Rays
/
Mice, Inbred ICR
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2007
Type:
Article
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