A Case of Essential Thrombocythemia Presenting as Esophageal Varix Bleeding and Multiple Thrombosis / 영남의대학술지
Yeungnam University Journal of Medicine
; : 99-104, 2011.
Article
in Ko
| WPRIM
| ID: wpr-117515
Responsible library:
WPRO
ABSTRACT
Essential thrombocythemia (ET), a subcategory of chronic myeloproliferative disorder, is characterized by absolute thrombocytosis due to excessive clonal proliferation of platelets, hyperaggregability of platelets, and increased incidence of thrombosis and hemorrhage. We consider a diagnosis of ET when an unexplained and persistent thrombocytosis is observed. It is difficult to consider ET first when we meet a patient with esophageal varix bleeding or unusual multiple thromboses like mesenteric vein, splenic vein, and portal vein. This article reports a patient who presented initially with esophageal varix bleeding and unusual multiple thromboses, thereafter, she was diagnosed with ET after testing positive for the Janus Tyrosine Kinase 2 (JAK2) V617F mutation. In conclusion, in patients with varix bleeding and unusual multiple thromboses, myeloproliferative disorders like essential thrombocythemia should be considered as a potential cause and testing for the JAK2 mutation is warranted.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Portal Vein
/
Splenic Vein
/
Thrombocytosis
/
Thrombosis
/
Varicose Veins
/
Blood Platelets
/
Esophageal and Gastric Varices
/
Incidence
/
TYK2 Kinase
/
Hemorrhage
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Yeungnam University Journal of Medicine
Year:
2011
Type:
Article