Treatment of Hemangiopericytoma-Associated Hypoglycemia with Glucocorticoid Therapy / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 77-83, 2011.
Article
in Korean
| WPRIM
| ID: wpr-117519
ABSTRACT
Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non-islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF II). Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stress, Psychological
/
Axis, Cervical Vertebra
/
Insulin-Like Growth Factor II
/
Prednisolone
/
Growth Hormone
/
Adrenal Glands
/
Fibrosarcoma
/
Glucocorticoids
/
Gluconeogenesis
/
Hemangiopericytoma
Limits:
Humans
Language:
Korean
Journal:
Yeungnam University Journal of Medicine
Year:
2011
Type:
Article
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