Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase
Journal of Korean Medical Science
;
: S42-S43, 2000.
Article
in English
| WPRIM
| ID: wpr-117526
ABSTRACT
1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) channel by elongating the open time of the channel. 3) cAMP signals were converted to a protein tyrosine kinase (PTK)-mediated signal. 4) The PTK-mediated signal was involved in the cAMP-stimulated Na+ transport in rat FDLE cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Biological Transport
/
Colforsin
/
Protein-Tyrosine Kinases
/
Chlorides
/
Rats, Wistar
/
Cyclic AMP
/
Adrenergic beta-Agonists
/
Tyrphostins
/
Respiratory Mucosa
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS