Serotonin and pancreatic duct function
Journal of Korean Medical Science
;
: S27-S28, 2000.
Article
in English
| WPRIM
| ID: wpr-117533
ABSTRACT
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Ducts
/
Vasodilator Agents
/
Secretin
/
Acetylcholine
/
Serotonin
/
5-Methoxytryptamine
/
Calcium
/
Guinea Pigs
/
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2000
Type:
Article
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