Serotonin and pancreatic duct function

Satoru NARUSE; Atsushi SUZUKI; Hiroshi ISHIGURO; Motoji KITAGAWA; Shigeru-BH KO; Toshiyuki YOSHIKAWA; Akiko YAMAMOTO; Hiroyuki HAMADA; Tetsuo HAYAKAWA

Satoru NARUSE; Atsushi SUZUKI; Hiroshi ISHIGURO; Motoji KITAGAWA; Shigeru-BH KO; Toshiyuki YOSHIKAWA; Akiko YAMAMOTO; Hiroyuki HAMADA; Tetsuo HAYAKAWA.

Journal of Korean Medical Science ; : S27-S28, 2000.

Article in English | WPRIM | ID: wpr-117533

ABSTRACT

ABSTRACT

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.

Subject(s)

5-Methoxytryptamine/pharmacology; Acetylcholine/pharmacology; Animals; Calcium/metabolism; Guinea Pigs; Pancreatic Ducts/metabolism; Pancreatic Ducts/drug effects; Secretin/pharmacology; Serotonin/pharmacology; Serotonin/metabolism; Serotonin/analogs & derivatives; Vasodilator Agents/pharmacology

Pancreatic Duct; Serotonin (5-HT); Fluid Secretion; Secretin; Acethylcholine

Fulltext

XML

Search on Google

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatic Ducts / Vasodilator Agents / Secretin / Acetylcholine / Serotonin / 5-Methoxytryptamine / Calcium / Guinea Pigs / Animals Language: English Journal: Journal of Korean Medical Science Year: 2000 Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

Search on Google