The Change of Cytokines by Risperidone in Patients with Schizophrenia / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 766-773, 2000.
Article
in Korean
| WPRIM
| ID: wpr-117545
ABSTRACT
OBJECT This study was carried out to evaluate immunologic difference between baseline and after 4 weeks drug treatment with atypical antipsychotics (rispreidone) by measurement of serum concentration of 6 cytokines. METHODS:
The subjets were composed of 25 patients who are admitted at Dajeon St's Marys hospital of psychiatry department and diagnosed as schizophrenia by DSM-IV diagnositc criteria. We measured serum IL-1beta, IL-2, IL-6, IL-12, INF-gamma, TNF-alpha concenatrations by quantitative ELISA method using ELISA kit (Endogen Inc., Woburn, MA, USA).The two psyciatrists performed PANSS examination between baseline and after 4 weeks risperidone treatments.RESULTS:
The serum level of IL-12 was increased significantly after medication of 4 weeks and the serum concentration of IFN-gamma showed the tendency of decreasement but not significant. The serum level of the other cytokines showed no significant change.CONCLUSIONS:
We spectulate that the increasement of IL-12 may contribute to role of activation of immune response by treatment of antipsychotic medication (risperidone). This study is first trial of IL-12 study in neuropsychiatric field and IL-12 which play important role of immune response becomes interesting subjects in immune research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Antipsychotic Agents
/
Enzyme-Linked Immunosorbent Assay
/
Cytokines
/
Interleukins
/
Interleukin-6
/
Interleukin-2
/
Tumor Necrosis Factor-alpha
/
Interleukin-12
/
Risperidone
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2000
Type:
Article
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