HLA-DQA1, HLA-DQB1, and HLA-DRB1 Allele Frequency in Korean Patients with Schizophrenia / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 746-753, 2000.
Article
in Korean
| WPRIM
| ID: wpr-117547
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate the correlation between HLA-DQA1, HLA-DQB1 and HLA-DRB1 alleles and disease susceptibility in Korean schizophrenic patients.METHODS:
HLA-DQA1, HLA-DQB1, and HLA-DRB1 allele typing were performed using polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) method in 128 Korean schizophrenic patients diagnosed by DSM-IV criteria, who were not blood-related, and 160 normal blood bank donors.RESULTS:
The HLA-DQB1*04 allele frequency was 14.6% in schizophrenic patients, which was significantly higher than that of normal controls which was 8.2% (p=0.028). HLA-DRB1*14 allele frequency was 11.8% in patients, which was also more frequent than that of normal controls which was 5.5% (p=0.01). HLA-DRB*15 allele frequency was 2.0% in patients, which was significantly lower than that of normal controls which was 7.1% (p=0.007) and HLA-DRB*16 allele frequency was 1.6% in patients, which was also lower than that of normal controls which was 4.8% (p=0.043).CONCLUSIONS:
Schizophrenia in Korea had positive correlation with HLA-DQB1*04 and HLA-DRB1*14, and negative correlation with HLA-DRB1*15 and HLA-DRB1*16. These findings support the association of the HLA-DQB1 and HLA-DRB1 with schizophrenia in Korean population, which was different from other study results in other different ethnic groups.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Schizophrenia
/
Tissue Donors
/
Blood Banks
/
Oligonucleotide Probes
/
Ethnicity
/
Diagnostic and Statistical Manual of Mental Disorders
/
Disease Susceptibility
/
Alleles
/
HLA-DRB1 Chains
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS