Molecular Characterization of sca Genes Found in Orientia tsutsugamushi Genome
Journal of Bacteriology and Virology
;
: 155-158, 2013.
Article
in Korean
| WPRIM
| ID: wpr-117654
ABSTRACT
Scrub typhus is an acute, febrile illness caused by Orientia tsutsugamushi infection and it is one of the main causes of acute febrile illness in the Asian-Pacific region. The incidence of scrub typhus has been significantly increased in Korea during last 10 years. Although early diagnosis and proper antibiotic treatment are important to prevent severe complications, the clinical discrimination of scrub typhus from other undifferentiated fevers, such as leptospirosis or dengue fever, is often very difficult. In addition, an effective vaccine has not yet been developed. As a novel diagnostic and vaccine target for scrub typhus, we described surface cell antigen (sca) family genes encoding autotransporter proteins found in the genome of O. tsutsugamushi. The molecular characteristics and recent findings on the bacterial genes were introduced in this letter.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orientia tsutsugamushi
/
Scrub Typhus
/
Proteins
/
Incidence
/
Genome
/
Dengue
/
Early Diagnosis
/
Discrimination, Psychological
/
Fever
/
Genes, Bacterial
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
/
Screening study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2013
Type:
Article
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