Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease
Intestinal Research
;
: 318-327, 2017.
Article
in English
| WPRIM
| ID: wpr-117804
ABSTRACT
Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decreasing the quality of life. Despite this, the management of intestinal BD has not been standardized. Empirical therapies including 5-aminosalicylic acid and corticosteroids have been used anecdotally to treat intestinal BD, but recent studies have provided evidence for the efficacy of anti-tumor necrosis factor α monoclonal antibodies. The development of agents targeting tumor necrosis factor α continues, it seems likely that they will change the therapeutic strategy and clinical outcomes of intestinal BD and inflammatory bowel disease. Monitoring disease activity such as endoscopic evaluation will become more important to obtain better outcomes. Here, we review current and future perspectives in the treatment and outcomes of intestinal BD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Stomatitis, Aphthous
/
Inflammatory Bowel Diseases
/
Tumor Necrosis Factor-alpha
/
Adrenal Cortex Hormones
/
Mesalamine
/
Antibodies, Monoclonal
/
Necrosis
Type of study:
Prognostic study
Language:
English
Journal:
Intestinal Research
Year:
2017
Type:
Article
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