Reference Values for Cystatin C Serum Concentrations in Children / 대한신장학회잡지
Korean Journal of Nephrology
;
: 75-79, 2001.
Article
in Korean
| WPRIM
| ID: wpr-118020
ABSTRACT
Cystatin C is a non-glycated 13-kilodalton basic protein produced by all nucleated cells. It has received considerable attention over the last few years as a potential replacement for creatinine as a biochemical marker for glomerular filtration rate(GFR). Recently published studies have shown that cystatin C correlates more strongly than creatinine with GFR. The aim of this study was to define a reference interval for cystatin C concentrations in children. Cystatin C was measured by an immunonephelometric assay in sera obtained from 102 children(47 boys, 55 girls, range from 1 year to 15 years) without evidence of kidney disease. The reference interval was calculated non-parametrically using the 2.5 th and 97.5th percentiles. Cystatin C concentration was constant regardless of age and sex, with a reference interval of 0.512-1.104mg/L. In contrast, serum creatinine concentration increased steadily with age until adulthood. Cystatin C offers easier recognition of renal function in childhood because its reference value is constant through all ages beyond 1 year.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Biomarkers
/
Creatinine
/
Cystatin C
/
Filtration
/
Glomerular Filtration Rate
/
Kidney Diseases
Limits:
Child
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2001
Type:
Article
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