Seizures in Patients with Brain Tumors
Journal of Korean Neurosurgical Society
;
: 387-390, 2007.
Article
in English
| WPRIM
| ID: wpr-118050
ABSTRACT
OBJECTIVES:
To determine the presentation, incidence, and risk factors of seizures in patients treated for brain tumors.METHODS:
One hundred patients who consecutively underwent a craniotomy for the treatment of supratentorial brain tumors were assessed. The pathologies of the patients enrolled in the study included glioma (n=56), meningioma (n=31), metastatic brain tumor (n=7), primary central nervous system lymphoma (n=4), and central neurocytoma (n=2). Anti-epileptic drugs (AEDs) were administered to all patients for up to six months after the surgery. Pre-defined variables for outcome analysis included tumor grade and location, extent of tumor resection, number of seizures, age at tumor diagnosis, adjuvant therapy, medication and radiological abnormalities.RESULTS:
Thirty patients (30%) presented at least a single episode of seizure at the time of admission. Five of these patients (16.7%) developed the seizure during the follow-up period. Newly developed seizure was noticed in six out of seventy patients (8.6%) without prior seizure. Histopathology was malignant gliomas in 10 and supratentorial meningioma in one. Early seizure developed only in two patients.CONCLUSION:
Compared with patients without seizure, patients with seizure at the time of admission showed younger age (p=0.003), a higher portion of low-grade glioma (p=0.001), tumor location in the frontal and temporal lobes (p=0.003) and cortical involvement (p=0.017). Our study suggestes that tumor progression is considered a significant risk factor for seizure development in glioma patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Seizures
/
Temporal Lobe
/
Brain
/
Brain Neoplasms
/
Central Nervous System
/
Incidence
/
Risk Factors
/
Follow-Up Studies
/
Neurocytoma
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2007
Type:
Article
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