The Effectiveness of Mitomycin C on Pterygium Surgery with Amniotic Membrane Transplantation
Journal of the Korean Ophthalmological Society
;
: 200-207, 2012.
Article
in Korean
| WPRIM
| ID: wpr-118097
ABSTRACT
PURPOSE:
To compare postoperative recurrence rates of pterygium surgery with amniotic membrane transplantation with and without mitomycin C.METHODS:
A retrospective analysis of 45 eyes of 43 patients who underwent pterygium surgery with amniotic membrane transplantation with a minimum of six months of follow-up. Nineteen eyes underwent mitomycin C application, while the remaining 26 eyes did not. Recurrence rates and complications were evaluated.RESULTS:
With a minimum of six months of follow-up, fibrovascular tissue in the excised area not invading the cornea (conjunctival recurrence) was noted in two eyes (10.5%), and fibrovascular tissue invading the cornea (corneal recurrence) was noted in one eye (5.4%) in the amniotic membrane transplantation with mitomycin C group. Conjunctival recurrence was noted in six eyes (23.1%) and corneal recurrence in three eyes (11.5%) in the amniotic membrane transplantation without mitomycin C group. Recurrence rate in the amniotic membrane transplantation with mitomycin C group (15.9%) was significantly lower (p = 0.014) than that in the amniotic membrane transplantation without mitomycin C group (34.6%). Complications included sub-amniotic membrane hemorrhage in two eyes, granuloma in one eye, and wound dehiscence in one eye in each group. There were no specific complications related to usage of mitomycin C.CONCLUSIONS:
In pterygium surgery with amniotic membrane transplantation, application of mitomycin C is an effective method to reduce recurrence rates, especially conjunctival recurrences that are related to cosmetic problems. This method may also be helpful to reduce patient discomfort.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Pterygium
/
Retrospective Studies
/
Follow-Up Studies
/
Mitomycin
/
Cornea
/
Transplants
/
Cosmetics
/
Eye
/
Granuloma
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2012
Type:
Article
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