A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring
Toxicological Research
;
: 139-141, 2012.
Article
in English
| WPRIM
| ID: wpr-118336
ABSTRACT
Silver nanoparticles (size 7.9 +/- 0.95 nm, dosage 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of the pups. Silver level in the treated group was 132.4 +/- 43.9 ng/g in the kidney (12.3 fold compared to control group), 37.3 +/- 11.3 ng/g in the liver (7.9 fold), 42.0 +/- 8.6 ng/g in the lung (5.9 fold), and 31.1 +/- 4.3 ng/g in the brain (5.4 fold). This result suggested that the possible transfer of silver nanoparticles from pregnant dams to the fetus through mainly placenta.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Silver
/
Brain
/
Parturition
/
Electrons
/
Nanoparticles
/
Fetus
/
Kidney
/
Liver
/
Lung
Limits:
Animals
Language:
English
Journal:
Toxicological Research
Year:
2012
Type:
Article
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