Procalcitonin and C-Reactive Protein in the Diagnosis and Prediction of Spontaneous Bacterial Peritonitis Associated With Chronic Severe Hepatitis B
Annals of Laboratory Medicine
;
: 449-454, 2013.
Article
in English
| WPRIM
| ID: wpr-118362
ABSTRACT
BACKGROUND:
Procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) are inflammatory markers used to diagnose severe bacterial infections. We evaluated the diagnostic role of these markers and compared their accuracy for spontaneous bacterial peritonitis (SBP) associated with chronic severe hepatitis B (CSHB).METHODS:
PCT and CRP concentrations, WBC count, and other hematological parameters were measured in serum from 84 well-characterized patients with CSHB, of whom 42 had SBP. Receiver operating characteristics (ROC) curve analysis was performed to assess the diagnostic accuracy.RESULTS:
PCT and CRP concentrations were significantly higher in the CSHB patients with SBP (n=42) than CSHB patients without SBP (n=42). PCT and CRP concentrations were more accurate than WBC count for the diagnosis of CSHB-associated SBP. The optimal cutoff value of PCT was 0.48 ng/mL. The PCT concentration was significantly correlated with the CRP concentration and WBC count.CONCLUSIONS:
Serum PCT and CRP seems to be better markers than WBC for the diagnosis of CSHB patients with SBP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritonitis
/
Protein Precursors
/
Temperature
/
Bacterial Infections
/
C-Reactive Protein
/
Calcitonin
/
Biomarkers
/
Sex Factors
/
ROC Curve
/
Age Factors
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2013
Type:
Article
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