The Clinical Outcome of Protocol R-11 Chemotherapy in Patients with Late Relapse of Childhood Acute Lymphoblastic Leukemia / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology
;
: 197-205, 2001.
Article
in Korean
| WPRIM
| ID: wpr-118598
ABSTRACT
PURPOSE:
This study is to see chemotherapeutic results followed by Rotational Combination Chemotherapy (R-11 protocol) treatment for the patients with late relapse of childhood ALL six months after the completion of chemotherapy.METHODS:
The subjects of study were the 13 children who had been diagnosed as ALL at the Severance Hospital and the Wonju Christian Hospital and completed the chemotherapy. They, however, diagnosed a late relapse of ALL between December, 1996 and December, 2001. After that, they were given an chemotherapy with R-11 protocol.RESULTS:
The average age of the 13 patients was 11.8 ( 2.8) years old at relapse. They showed the complete remission (8 patients, 61%), partial remission (4, 31%), and induction failure (1, 8%). The total remission ratio was 92%. Four year Event Free Survival (EFS) after the second remission was 61.5%. They also showed acute toxicity during remission induction with severe than grade III according to the WHO criteria. The leukopenia and thrombocytopenia (hematologic toxicity) were seen at 11 cases (84%) and 9 cases (69%) respectively, and hepatotoxicity (non-hematologic toxicity) was shown at 6 cases (46%). There are also chronic toxicity, one case developed leukomalacia, and 6 cases did various symptoms of infections.CONCLUSION:
There is no optimal chemotherapeutic protocol for late relapse of childhood ALL, and the treatment with R-11 protocol is worth a trial.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Thrombocytopenia
/
Remission Induction
/
Disease-Free Survival
/
Drug Therapy
/
Drug Therapy, Combination
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Leukopenia
Type of study:
Practice guideline
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatric Hematology-Oncology
Year:
2001
Type:
Article
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