Optimized Tacrolimus Therapy in the Early Stage after Renal Transplantation
Journal of the Korean Surgical Society
;
: 428-435, 2010.
Article
in Korean
| WPRIM
| ID: wpr-118659
ABSTRACT
PURPOSE:
Immunosuppressive regimen based on reduced-dose Tacrolimus (TAC) is widely accepted in the field of renal transplantation. However, optimal targetsfor TAC whole blood trough concentrations during the early period after kidney transplantation remain uncertain.METHODS:
A total of 184 consecutive adult renal transplant recipients with triple immunosuppression (TAC/Mycophenolate/corticosteroid) were included in this study. According to the trough level of TAC at day 7 after transplantation, patients were classified as low TAC concentration (LT, 15 ng/ml, n=24) groups. Rate of acute rejection, graft function and side effects of TAC within 1 yr after transplantation were evaluated.RESULTS:
There was no difference in trough concentrations of TAC at 2 weeks, 1 month, 3 months, 6 months and 12 months after transplantation among the three groups. Significantly higher incidence of acute rejection within 2 weeks after transplantation was observed in LT group compared with IT and HT groups (17.4%, 5.6% and 4.8%, respectively, P=0.037). HT patients showed significantly better estimated glomerular filtration rates until 6 months after transplantation than IT and LT patients (75.5+/-24.8 vs. 63.8+/-12.8 and 64.3+/-15.2 ml/min at 6 months, P=0.03). There was no significant difference in TAC toxicity in terms of post-transplant diabetes and renal toxicity.CONCLUSION:
Short-term high TAC exposure immediately after kidney transplantation may provide lower incidence of acute rejection and better restoration of graft function compared with low or intermediate TAC exposure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rejection, Psychology
/
Incidence
/
Immunosuppression Therapy
/
Kidney Transplantation
/
Tacrolimus
/
Transplants
/
Glomerular Filtration Rate
/
Graft Rejection
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2010
Type:
Article
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