Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments
Journal of Korean Neurosurgical Society
;
: 325-331, 2010.
Article
in English
| WPRIM
| ID: wpr-118912
ABSTRACT
OBJECTIVE:
We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC).METHODS:
Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 +/- 13 years, and 17 (85.0%) were men. Seventeen (85.0%) patients had already extracranial metastases. The median time from diagnosis of HCC to brain metastasis was 18.5 months. Fourteen (70.0%) patients had stroke-like presentation due to intracerebral hemorrhage (ICH). Ten (50.0%) patients had single or solitary brain metastasis. Among a total of 34 brain lesions, 31 (91.2%) lesions had the hemorrhagic components.RESULTS:
The median survival time was 8 weeks (95% CI, 5.08-10.92), and the actuarial survival rates were 85.0%, 45.0%, 22.5%, and 8.4% at 4, 12, 24, and 54 weeks. Age < 60 years, treatment of the primary and/or extracranial lesions, and recurrent ICH were the possible prognostic factors (p = 0.044, p < 0.001, and p = 0.111, respectively). The median progression-free survival (PFS) time was 3 months (95% CI, 0.95-5.05).CONCLUSION:
The overall survival of the patients with brain metastasis from HCC was very poor with median survival time being only 8 weeks. However, the younger patients less than 60 years and/or no extracranial metastases seem to be a positive prognostic factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Cerebral Hemorrhage
/
Survival Rate
/
Retrospective Studies
/
Carcinoma, Hepatocellular
/
Disease-Free Survival
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2010
Type:
Article
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