Clinicopathologic Characteristics and Prognosis of Endometrial Cancer: A study of 56 Cases / 대한산부인과학회잡지

ABSTRACT

OBJECTIVES: This study was performed to evaluate the clinicopathologic characteristics and prognosis of uterine endometrial cancer to identify risk factors of the therapeutic and prognostic values. METHODS: This retrospective study was based on medical records including operation records and pathologic reports of 56 patients who underwent surgical treatment with histologically proven endometrial cancer at Kyung-Hee University Medical Center from Sep. 1979 to Aug. 2001. The survival of patients was determined by description of last follow up date in medical records. If more than 3 months passed from last follow up date, we used mail and phone call to identify the status of patients. Univariate analysis was carried out to compare the importance of prognostic variables. RESULTS: The mean age of these patients was 52.4 years, the most common presenting symptom was abnormal vaginal bleeding (91.1%). All except 2 cases of papillary serous carcinoma (3.6%) and 1 case of clear cell carcinoma (1.8%) were endometrioid adenocarcinoma (94.6%). And there are 6 cases of endometrial carcinoma with squamous differentiation. The grades were classified into grade 1 (53.6%), grade 2 (26.8%), grade 3 (19.6%). The FIGO surgical stages were classified into stage\\'a5\\'b0 (55.4%), stage \\'a5\\'b1 (7.1%), stage \\'a5\\'b2 (30.4%), stage \\'a5\\'b3 (7.1%). Most of the patients (87.5%) were treated by surgery only or surgery followed by adjuvant radiotherapy. The overall 5 years survival rate (5YSR) was 65.6% The FIGO surgical stage \\'a5\\'b0 83.3%; stage \\'a5\\'b1 66.7%; stage \\'a5\\'b2 37.5%; stage \\'a5\\'b3 33.3%. Recurrent case was only one case. The age, parity, and preoperative Pap test were not significant prognostic factors. The depth of myometrium invasion (p<0.05), FIGO surgical stage (p<0.05), peritoneal cytology (p<0.05) and lymph node metastasis (p<0.05) were significant prognostic factors by univariate analysis. CONCLUSIONS: Although the number of patients was not enough, the depth of myometrial invasion, FIGO surgical stage and lymph node metastasis seemed to be significant prognostic factors of uterine endometrial cancer.