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Association between Elevated Pleural Interleukin-33 Levels and Tuberculous Pleurisy
Annals of Laboratory Medicine ; : 45-51, 2013.
Article in English | WPRIM | ID: wpr-119341
ABSTRACT

BACKGROUND:

Interferon-gamma (IFN-gamma) plays a crucial role in Mycobacterium tuberculosis induced pleural responses. Interleukin (IL)-33 up-regulates the production of IFN-gamma. We aimed to identify whether an association between pleural IL-33 levels and tuberculous pleurisy exists and determine its diagnostic value.

METHODS:

Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-gamma, as well as serum IL-33 and ST2 were measured in 220 patients with pleural effusions (PEs). Patients with malignant (MPEs), parapneumonic (PPEs), tuberculous (TPEs), and cardiogenic (CPEs) pleural effusions were included.

RESULTS:

Pleural and serum IL-33 levels were highest or tended to be higher in patients with TPEs than in those with other types of PEs. The median pleural fluid-to-serum IL-33 ratio was higher in TPE cases (> or = 0.91) than in other PE cases (< or = 0.56). Pleural IL-33 levels correlated with those of pleural ADA and IFN-gamma. However, the diagnostic accuracies of pleural IL-33 (0.74) and pleural fluid-to-serum IL-33 ratio (0.75) were lower than that of ADA (0.95) or IFN-gamma (0.97). Pleural ST2 levels in patients with MPEs were higher than in patients with TPEs. Serum ST2 levels did not differ among the groups.

CONCLUSIONS:

We identified an association between elevated pleural IL-33 levels and tuberculous pleurisy. However, we recommend conventional pleural markers (ADA or IFN-gamma) as diagnostic markers of TPE.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pleural Effusion / Tuberculosis, Pleural / Case-Control Studies / Adenosine Deaminase / Cross-Sectional Studies / ROC Curve / Pleural Effusion, Malignant / Interleukins / Interferon-gamma / Receptors, Cell Surface Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Annals of Laboratory Medicine Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pleural Effusion / Tuberculosis, Pleural / Case-Control Studies / Adenosine Deaminase / Cross-Sectional Studies / ROC Curve / Pleural Effusion, Malignant / Interleukins / Interferon-gamma / Receptors, Cell Surface Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Annals of Laboratory Medicine Year: 2013 Type: Article