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The variation of thiodiglycolic acid concentration in urine with vinyl chloride exposure levels in rats / 대한산업의학회지
Korean Journal of Occupational and Environmental Medicine ; : 431-438, 1999.
Article in Korean | WPRIM | ID: wpr-119575
ABSTRACT

OBJECTIVES:

It is the objective of this research to identify the variation of thiodiglycolic acid (TdGA) in urine with vinyl chloride monomer (VCM) exposure levels through methylation.

METHODS:

After rats were exposed to vinyl chloride monomer of 4 levels, 0 mg/m3, 50 mg /m3, 150 mg/m3, 500 mg/m3, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 24 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done.

RESULTS:

In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary .TdGA concentration in urine according to exposure level of VCM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified.

CONCLUSION:

TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Vinyl Chloride / Diazomethane / Methylation Limits: Animals Language: Korean Journal: Korean Journal of Occupational and Environmental Medicine Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vinyl Chloride / Diazomethane / Methylation Limits: Animals Language: Korean Journal: Korean Journal of Occupational and Environmental Medicine Year: 1999 Type: Article