Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells
Experimental & Molecular Medicine
;
: 380-386, 2004.
Article
in English
| WPRIM
| ID: wpr-119638
ABSTRACT
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many types of tumor tissues. Trifluoperazine (TFP), a phenothiazine class of antipsychotics, restored serum-induced Egr-1 expression in several cancer cell lines. We investigated the effect of Egr-1 expression on the TFP-induced inhibition of cell growth. Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells. Our results suggest that antipsychotics TFP exhibits antiproliferative activity through up-regulation of Egr-1.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
Trifluoperazine
/
Tumor Cells, Cultured
/
Gene Expression
/
Cell Cycle
/
Promoter Regions, Genetic
/
Immediate-Early Proteins
/
Cyclin D1
/
Cell Proliferation
/
DNA-Binding Proteins
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2004
Type:
Article
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