Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis
Experimental & Molecular Medicine
;
: 432-439, 2012.
Article
in English
| WPRIM
| ID: wpr-119838
ABSTRACT
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by modulating oxidative stress. Intragastric administration of PtNP reduced ovariectomy (OVX)-induced bone loss with a decreased level of activity and number of osteoclast (OC) in vivo. PtNP inhibited OC formation by impairing the receptor activator of nuclear factor-kappaB ligand (RANKL) signaling. This impairment was due to a decreased activation of nuclear factor-kappaB and a reduced level of nuclear factor in activated T-cells, cytoplasmic 1 (NFAT2). PtNP lowered RANKL-induced long lasting reactive oxygen species as well as intracellular concentrations of Ca2+ oscillation. Our data clearly highlight the potential of PtNP for the amelioration of bone loss after estrogen deficiency by attenuated OC formation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Osteoporosis
/
Platinum
/
Ovariectomy
/
Signal Transduction
/
Reactive Oxygen Species
/
Oxidative Stress
/
NFATC Transcription Factors
/
RANK Ligand
/
Metal Nanoparticles
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2012
Type:
Article
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