The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea
Gut and Liver
;
: 321-327, 2012.
Article
in English
| WPRIM
| ID: wpr-119855
ABSTRACT
BACKGROUND/AIMS:
The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition.METHODS:
We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195 genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms.RESULTS:
The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765 genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX-2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% confidence interval, 1.077 to 35.870).CONCLUSIONS:
The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptic Ulcer
/
Stomach Neoplasms
/
Logistic Models
/
Odds Ratio
/
Polymerase Chain Reaction
/
Prevalence
/
Risk Factors
/
Prostaglandin-Endoperoxide Synthases
/
Gastrointestinal Tract
/
Genotype
Type of study:
Etiology study
/
Prevalence study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Gut and Liver
Year:
2012
Type:
Article
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