Your browser doesn't support javascript.
loading
Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
Journal of Korean Medical Science ; : 572-575, 2012.
Article in English | WPRIM | ID: wpr-119890
ABSTRACT
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of the left anterior descending coronary artery, followed by 2 hr reperfusion. Sauchinone (10 mg/kg) was administered intraperitoneally 30 min before the onset of ischemia. The infarct size was measured 2 hr after resuming the perfusion. The expression of cell death kinases (p38 and JNK) and reperfusion injury salvage kinases (phosphatidylinositol-3-OH kinases-Akt, extra-cellular signal-regulated kinases [ERK1/2])/glycogen synthase kinase (GSK)-3beta was determined 5 min after resuming the perfusion. Sauchinone significantly reduced the infarct size (29.0% +/- 5.3% in the sauchinone group vs 44.4% +/- 6.1% in the control, P < 0.05). Accordingly, the phosphorylation of JNK and p38 was significantly attenuated, while that of ERK1/2, Akt and GSK-3beta was not affected. It is suggested that sauchinone protects against regional myocardial I/R injury through inhibition of phosphorylation of p38 and JNK death signaling pathways.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorylation / Benzopyrans / Myocardial Reperfusion Injury / Signal Transduction / Mitogen-Activated Protein Kinase 1 / Protective Agents / Glycogen Synthase Kinase 3 / Mitogen-Activated Protein Kinase 3 / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases Limits: Animals Language: English Journal: Journal of Korean Medical Science Year: 2012 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorylation / Benzopyrans / Myocardial Reperfusion Injury / Signal Transduction / Mitogen-Activated Protein Kinase 1 / Protective Agents / Glycogen Synthase Kinase 3 / Mitogen-Activated Protein Kinase 3 / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases Limits: Animals Language: English Journal: Journal of Korean Medical Science Year: 2012 Type: Article