A study on the Relationship of the Severity of Psoriasis, Serum Soluble E-selectin, MCP-1 and RANTES / 대한피부과학회지
Korean Journal of Dermatology
;
: 138-144, 2004.
Article
in Korean
| WPRIM
| ID: wpr-11990
ABSTRACT
BACKGROUND:
Psoriasis is a chronic skin disease characterized histologically by prominent keratinocyte hyperplasia and an early inflammatory cell infiltrate. However, the pathogenesis is not fully understood yet. Recently, the evidence that T lymphocytes play a key role in the pathogenesis of psoriasis is compelling.OBJECTIVE:
The purpose of this study is to evaluate serum soluble E-selectin, MCP-1 and RANTES as severity indices or disease marker. In this study, we investigated a possible correlation between disease activity in psoriasis and serum soluble E-selectin, MCP-1 and RANTES, respectively.METHODS:
Fifteen patients with psoriasis and fifteen normal controls were included in this study. The patients were evaluated for the symptoms and signs according to PASI score. We measured soluble E-selectin, MCP-1 and RANTES levels with blood samples drawn from patients and normal controls.RESULTS:
1. Soluble E-selectin serum levels were significantly increased in psoriatic patients compared with normal controls (p<0.05). Moreover, a significant correlation was demonstrated between serum soluble E-selectin values and PASI scores (r=0.54, p<0.05). 2. Serum MCP-1 levels were significantly increased in psoriatic patients compared with normal conrols (p<0.05). However, no significant correlation was observed between MCP-1 values and PASI scores (r=-0.12). 3. Serum RANTES levels were significantly increased in psoriatic patients compared with normal controls (p<0.05). Moreover, a positive correlation was observed between serum RANTES levels and PASI scores (r=0.63, p<0.05).CONCLUSION:
These results suggest that serum levels of soluble E-selectin and RANTES could be used as marker of the disease activity in psoriatic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
Skin Diseases
/
T-Lymphocytes
/
Keratinocytes
/
Chemokine CCL5
/
E-Selectin
/
Hyperplasia
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS