Expression of Beta-catenin and E-cadherin in Early Gastric Cancer: Correlation with Clinicopathologic Parameters / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 82-89, 2004.
Article
in Korean
| WPRIM
| ID: wpr-12001
ABSTRACT
BACKGROUND/AIMS:
Beta-catenin is known to perform two unrelated functions in cadherin-mediated cell to cell adhesion system and Wnt pathway. Recent studies reported cytoplasmic and nuclear accumulation of beta-catenin by Wnt signaling and/or abnormal Wnt pathway in cancer cells. Nuclear accumulations of beta-catenin have a crucial role in early tumor growth and initiation of invasive growth in gastric cancer.METHODS:
We carried out clinicopathological and immunohistochemical studies for beta-catenin, p53, E-cadherin, and Ki-67 in the specimens from 60 early gastric cancer patients who were treated with curative resections.RESULTS:
Twenty-five (41.7%) and twenty-nine (48.3%) cases showed a nuclear and cytoplasmic expression of beta-catenin, respectively. There were significant correlations between nuclear expression of beta-catenin and well-differentiated and intestinal type of early gastric carcinoma. Cytoplasmic expression of beta-catenin had significant correlations with nuclear expression of beta-catenin (p=0.011).CONCLUSIONS:
Nuclear expression of beta-catenin is significantly influenced by histological grade, Lauren classification and cytoplasmic expression of beta-catenin in early gastric cancer. These findings suggest that nuclear expression of beta-catenin is correlated with early tumorigenesis and initiation of invasive growth in gastric cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
English Abstract
/
Carcinoma
/
Cadherins
/
Trans-Activators
/
Cell Nucleus
/
Tumor Suppressor Protein p53
/
Ki-67 Antigen
/
Cytoplasm
/
Cytoskeletal Proteins
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2004
Type:
Article
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