Factors associated with clinical severity determined by requirement for systemic corticosteroid therapy in adult asthmatic patients / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 1169-1178, 2001.
Article
in Korean
| WPRIM
| ID: wpr-120222
ABSTRACT
BACKGROUND:
Most studies involving factor analysis on clinical severity of bronchial asthma are short-term and cross-sectional.OBJECTIVES:
We evaluated the clinical severity of bronchial asthma according to requirement of systemic corticosteroid therapy, and analyzed the factors associated with long-term systemic corticosteroid therapy.METHODS:
The records of 158 asthmatic patients (including 76 patients followed for one year) visiting the clinic of Allergy-Immunology of Ajou University Hospital between June, 1997 and May, 1999 were reviewed retrospectively.RESULTS:
Among the 76 asthmatic patients who had been followed-up for one year, asthmatic patients (n=28) treated with systemic corticosteroid for more than 60 days had lower initial FEV1(% predicted) values (p=0.001), lower prevalence of concomitant allergic diseases (p= 0.04), and lower frequency of allergen-specific immunotherapy (p=0.006) than asthmatic patients treated with systemic corticosteroid for less than 60 days (n=48). Among the 158 asthmatic patients, 87 patients (55%) were atopic asthmatics and 71 patients (45%) were nonatopic asthmatics. Nonatopic asthmatics showed older age at initial visit (p<0.001), lower serum total IgE levels (p=0.02), lower prevalence of concomitant allergic diseases (p=0.004), and higher prevalence of aspirin-sensitivity (p<0.001) than atopic asthmatic patients. Among the 76 patients followed for one year, nonatopic asthmatic patients were treated with significantly higher cumulative-doses of systemic steroid than atopic asthmatic patients (p=0.04).CONCLUSION:
Initial pulmonary function and nonatopy are significantly associated with clinical severity determined by requirement of systemic corticosteroid therapy in adult asthmatic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Immunoglobulin E
/
Prevalence
/
Retrospective Studies
/
Immunotherapy
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
2001
Type:
Article
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