Efficacy of Pre- and Postoperative Chemotherapy in Patients with Osteosarcoma of the Extremities / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 520-526, 2001.
Article
in Korean
| WPRIM
| ID: wpr-120296
ABSTRACT
PURPOSE:
We evaluated the treatment efficacy including survival and recurrence, and factors associated with recurrence in osteosarcoma patients treated with preoperative chemotherapy, surgery, and adjuvant chemotherapy. MATERIALS ANDMETHODS:
Forty nine patients with osteosarcoma were treated with preoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion for 3 cycles, followed by surgery. According to the pathologic response, if tumor was necrotized more than 90%, the same adjuvant chemotherapy was reintroduced for 3 cycles, and if the response was not enough, then the salvage regimen was introduced. Plain chest film and chest CT scan were taken monthly and every 3 months, respectively. When tumor recurred, the metastasectomy was performed whenever possible.RESULTS:
Forty three patients were evaluable with amedian follow up of 53 months. Five-year disease-free and overallsurvival rate was 47.0% and 66.9%, respectively. The recurrence was observed in 22 patients (51.2%) with median time of 12.5 months. Baseline alkaline phosphatase (ALP) was the only significant factor for recurrence (p=0.03) and the patients with the possibility of metastasectomy recurrence showed higher post-relapse survival compared to other treatment modalities (26 momths vs 5~12 months).CONCLUSION:
These results indicates that pre- and postoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion showed comparable treatment efficacy and acceptable toxicities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Thorax
/
Doxorubicin
/
Tomography, X-Ray Computed
/
Osteosarcoma
/
Follow-Up Studies
/
Cisplatin
/
Treatment Outcome
/
Chemotherapy, Adjuvant
/
Drug Therapy
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Cancer Research and Treatment
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS