Effects of a New Antipsychotic Drug (YKP1447) on Impaired Prepulse Inhibition Induced by Apomorphine and Phencyclidine in Rats / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 38-45, 2008.
Article
in Korean
| WPRIM
| ID: wpr-120563
ABSTRACT
OBJECTIVE:
Schizophrenia, a devastating mental disorder, displays a wide range of cognitive impairments including attentional impairment. Prepulse inhibition (PPI), in which a startle response to a loud acoustic noise is reduced by a preceding auditory stimulus of a lower intensity, is impaired in schizophrenic patients and rats injected with apomorphine (APO) or phencyclidine (PCP) mimicking attentional deficits in schizophrenics. Here we examined therapeutic efficacy of a newly developed atypical antipsychotic compound (YKP1447;YKP) on PPI impairment induced by various doses of APO and PCP.METHODS:
This study was composed of 3 experiments. YKP (0.5-15 mg/kg) or vehicle (VEH) was administered 15 min before the injection of APO (0.5 mg/kg, Exp1) or PCP (2.0 mg/kg, Exp21.5 mg/kg, Exp3). They were then tested for PPI in which a mix of startle stimulus and prepulse was presented.RESULTS:
APO or PCP treatment effectively impaired PPI in tested animals (VEH/APO or VEH/PCP). Impaired PPI in APO group was reversed in animals that were pretreated with YKP (5-10 mg/kg) (Exp1). However YKP treatment was not effective in PCP group (Exp2-3).CONCLUSION:
High concentration of YKP pretreatment had antipsychotic effect on APO-induced impairment in attentional function suggesting that the compound could potentially be used to treat cognitive impairment due to increased dopaminergic receptorbinding.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phencyclidine
/
Schizophrenia
/
Antipsychotic Agents
/
Acoustics
/
Apomorphine
/
Mental Disorders
/
Noise
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2008
Type:
Article
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