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The trend in the eradication rates of first- and second-line therapy for Helicobacter pylori infection in Daegu and Kyungpook provinces: a single center experience for the most recent 9 years / 대한내과학회지
Korean Journal of Medicine ; : 186-192, 2009.
Article in Korean | WPRIM | ID: wpr-120691
ABSTRACT
BACKGROUND/

AIMS:

The reported prevalence of antibiotic resistance in Helicobacter pylori infection has been increasing. However, recent trends in the eradication rates of H. pylori using first-line triple regimens are rarely reported. Therefore, we determined the trend in the H. pylori eradication rates in a single center for the most recent 9 years in Daegu and Kyungpook provinces, Korea.

METHODS:

From January 1999 through December 2007, the eradication rates in 615 H. pylori-positive patients who received one-week triple regimens were evaluated retrospectively according to year and ulcer location.

RESULTS:

The overall H. pylori eradication rate was 81.6%. The eradication rate from the years 1999 to 2007 was 76.3, 78.3, 82.8, 88.5, 77.8, 91.7, 84.8, 75.4, and 83.7%, respectively, based on the per-protocol analysis. No definite evidence of a decreasing tendency of the eradication rate was seen over the 9 years (p=0.760). Furthermore, there was no significant difference in the eradication rate according to ulcer location.

CONCLUSIONS:

There is no decreasing trend in the H. pylori eradication rate over the past 9 years in Daegu and Kyungpook provinces. However, the eradication rates are not satisfactory, and further investigation is needed to develop more effective regimens.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Ulcer / Drug Resistance, Microbial / Prevalence / Retrospective Studies / Helicobacter pylori / Helicobacter / Korea Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Medicine Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ulcer / Drug Resistance, Microbial / Prevalence / Retrospective Studies / Helicobacter pylori / Helicobacter / Korea Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Medicine Year: 2009 Type: Article