The trend in the eradication rates of first- and second-line therapy for Helicobacter pylori infection in Daegu and Kyungpook provinces: a single center experience for the most recent 9 years / 대한내과학회지
Korean Journal of Medicine
;
: 186-192, 2009.
Article
in Korean
| WPRIM
| ID: wpr-120691
ABSTRACT
BACKGROUND/AIMS:
The reported prevalence of antibiotic resistance in Helicobacter pylori infection has been increasing. However, recent trends in the eradication rates of H. pylori using first-line triple regimens are rarely reported. Therefore, we determined the trend in the H. pylori eradication rates in a single center for the most recent 9 years in Daegu and Kyungpook provinces, Korea.METHODS:
From January 1999 through December 2007, the eradication rates in 615 H. pylori-positive patients who received one-week triple regimens were evaluated retrospectively according to year and ulcer location.RESULTS:
The overall H. pylori eradication rate was 81.6%. The eradication rate from the years 1999 to 2007 was 76.3, 78.3, 82.8, 88.5, 77.8, 91.7, 84.8, 75.4, and 83.7%, respectively, based on the per-protocol analysis. No definite evidence of a decreasing tendency of the eradication rate was seen over the 9 years (p=0.760). Furthermore, there was no significant difference in the eradication rate according to ulcer location.CONCLUSIONS:
There is no decreasing trend in the H. pylori eradication rate over the past 9 years in Daegu and Kyungpook provinces. However, the eradication rates are not satisfactory, and further investigation is needed to develop more effective regimens.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ulcer
/
Drug Resistance, Microbial
/
Prevalence
/
Retrospective Studies
/
Helicobacter pylori
/
Helicobacter
/
Korea
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2009
Type:
Article
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