The Effect of Intravitreal Melatonin on Rabbit Retina
Journal of the Korean Ophthalmological Society
;
: 1781-1788, 2002.
Article
in Korean
| WPRIM
| ID: wpr-120740
ABSTRACT
PURPOSE:
To investigate the effect of intravitreal melatonin on retina in rabbit.METHODS:
In four pigmented rabbit, melatonin was intravitreally injected 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration in left eye, DMSO was injected in right eye as control. we examined gross fundus finding and electroretinogram and then light and electronic microscopic findings at 24 hours and 1 week with both eye.RESULTS:
intravitreally melatonin injected eye at 100 mu g/0.1 ml, 300 mu g/0.1 ml concentration and control eye at 1 day and 1 week, significant difference was not shown in gross fundus finding, electroretinogram, light and electronic microscopic finding. Additionally edema, toxic effect change was not found in retina.CONCLUSIONS:
Intravitreally injected melatonin has not influenced on retina grossly, histologically, physiologically at 100 mu g/0.1 ml and 300 mu g/0.1 ml concentration. Further study is required about toxic effect of melatonin over 300 mu g/0.1 ml concentration and clinical usefulness of melatonin in retina.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retina
/
Dimethyl Sulfoxide
/
Edema
/
Intravitreal Injections
/
Melatonin
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2002
Type:
Article
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