Sirolimus-induced pneumonitis in a renal transplant recipient / 대한내과학회지
Korean Journal of Medicine
; : 438-442, 2010.
Article
in Ko
| WPRIM
| ID: wpr-120826
Responsible library:
WPRO
ABSTRACT
Sirolimus is a promising immunosuppressive agent with low nephrotoxicity and anti-tumor effects; it replaces calcineurin inhibitors, but serious adverse effects have been reported. We report on sirolimus-induced pneumonitis, which is a rare but fatal complication. The patient was a 51-year-old renal transplant recipient who had received sirolimus for 3 months before admission. The patient had a productive cough and mild fever, which began 3 weeks before admission. The chest PA and CT findings were consistent with pneumonia, but a microbiological study and bronchoscopic findings revealed no evidence of infection. Sirolimus-induced pneumonitis was suspected, so the sirolimus was stopped and high-dose steroids were initiated. The respiratory symptoms and radiologic findings improved dramatically after sirolimus withdrawal and the initiation of steroid treatment. These findings strongly suggest a casual relationship between sirolimus and pneumonitis. This is the first case of sirolimus-induced pneumonitis in Korea.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pneumonia
/
Steroids
/
Thorax
/
Calcineurin
/
Transplants
/
Sirolimus
/
Cough
/
Fever
/
Korea
Limits:
Humans
Country/Region as subject:
Asia
Language:
Ko
Journal:
Korean Journal of Medicine
Year:
2010
Type:
Article