Contraction and Relaxation Responses of Isolated Rabbit Seminal Vesicle to Selective beta Subtypes-adrenoceptor Agonists and Antagonists / 대한비뇨기과학회지
Korean Journal of Urology
;
: 726-731, 2004.
Article
in Korean
| WPRIM
| ID: wpr-120838
ABSTRACT
PURPOSE:
This study was aimed at investigating the role of betaadrenoceptor subtypes in mediating the relaxation and contraction of seminal vesicles in rabbits. MATERIALS ANDMETHODS:
Relaxation or contractile responses of epithelium- removed muscle strips of a rabbit seminal vesicle, which were precontracted with 10-5M norepinephrine, to selective betasubtypes-adrenoceptor agonists were observed in an organ bath. The contractile responses induced by isoproterenol were also observed after application of selective antagonists.RESULTS:
Isoproterenol showed a concentration-dependent contractile response, but the contractility was weaker than those with phenylephrine and norepinephrine. The betaselective-agonists(xamoterol for beta, clenbuterol for beta and BRL37344 for beta) alone evoked neither contraction nor relaxation. However, the beta- and beta-agonists inhibited the contraction of the precontracted strips with 10-5M norepinephrine, while the beta-agonist enhanced the contraction. The pretreatment with a beta-antagonist(ICI118551) reduced the tension of the strips developed by 10-4M isoproterenol, but the beta-(atenolol) and beta-(SR59230A) antagonists showed no changes in the response.CONCLUSIONS:
beta- and beta-adrenoceptors seem to mediate the relaxation of the seminal vesicle, while the beta-adrenoceptor may have a supplementary role in contraction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylephrine
/
Relaxation
/
Seminal Vesicles
/
Baths
/
Norepinephrine
/
Negotiating
/
Clenbuterol
/
Isoproterenol
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2004
Type:
Article
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