Hippocampal Neurochemical Pathology in Patients with Panic Disorder
Psychiatry Investigation
;
: 161-165, 2012.
Article
in English
| WPRIM
| ID: wpr-120916
ABSTRACT
OBJECTIVE:
In the present study, we measured hippocampal N-acetyl-l-aspartate (NAA), choline (CHO) and creatine (CRE) values in patients with panic disorder and healthy control subjects using in vivo 1H MRS.METHODS:
We scanned 20 patients meeting Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for panic disorder and 20 matched healthy controls with a 1.5 Tesla GE Signa Imaging System and measured of NAA, CHO, and CRE in hippocampal regions.RESULTS:
When NAA, CHO and CRE values were compared between groups, statistically significant lower levels for all ones were detected for both sides.CONCLUSION:
Consequently, in the present study we found that NAA, CHO and CRE values of the patients with panic disorder were lower than those healthy controls. Future studies involving a large number of panic patients may shed further light on the generalizability of the current findings to persons with panic disorder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Panic
/
Choline
/
Panic Disorder
/
Aspartic Acid
/
Creatine
/
Light
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS