Early Experience of Intravesical Capsaicin for Treatment of Detrusor Hyperreflexia in Patients with Spinal Cord Injury
Journal of the Korean Continence Society
;
: 50-56, 2000.
Article
in Korean
| WPRIM
| ID: wpr-120957
ABSTRACT
PURPOSE:
The clinical and urodynamic effects of intravesical capsaicin, a neurotoxic substance causing a reversible suppression of unmyelinated C fiber afferent neuronal activity, were investigated for treatment of detrusor hyperreflexia in patients with spinal cord injury. MATERIALS ANDMETHODS:
Capsaicin solution (2mM) dissolved in 30% alcohol was instilled intravesically in 7 men with detrusor hyperreflexia due to spinal cord injury. Effects on bladder function and subjective symptoms were evaluated before and after intravesical instillation of capsaicin.RESULTS:
Bladder function was improved in all but 1 patient. The improvement was expressed as an increase from 108ml to 270ml in maximal bladder capacity and a decrease from 75cmH2O to 44cmH2O in maximal detrusor pressure. Four patients had subjective improvement following treatment and the effects lasted for 4 to 6 weeks. Immediately after capsaicin instillation the ice water test was negative in 2 patients. Autonomic dysreflexia was observed in 4 patients, suprapubic discomfort in 3 patients and gross hematuria in 1 patient.CONCLUSION:
Intravesical capsaicin seems to be a promising method for treatment of detrusor hyperreflexia, but the general use of intravesical capsaicin was limited due to side effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord Injuries
/
Urodynamics
/
Urinary Bladder
/
Administration, Intravesical
/
Water
/
Capsaicin
/
Reflex, Abnormal
/
Autonomic Dysreflexia
/
Nerve Fibers, Unmyelinated
/
Hematuria
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Continence Society
Year:
2000
Type:
Article
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