Effects of Some Local Anesthetics on Ca++ Binding to Lipid-Extracted RBC Membrane, Egg Albumin Film and Filter Paper
Yonsei Medical Journal
;
: 1-9, 1973.
Article
in English
| WPRIM
| ID: wpr-12096
ABSTRACT
Local anesthetics at a concentration of 10 mM(procaine and lidocaine) were found to inhibit competitively Ca++ binding to lipidextracted RBC membrane, and also to egg albumin film fixed on cover glasses or impregnated into Whatman filter paper (No. 1). A competitive inhibition by local anesthetics was also found in Ca++ binding to Whatman filter paper which had been pretreated with organic solvents to extract possible contaminated lipids. Therefore, it is suggested that the local anesthetics inhibit Ca++ binding not only to phospholipids but to some macromolecules such as membrane proteins, egg albumin film and filter paper.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Procaine
/
Cell Membrane Permeability
/
Ovalbumin
/
Calcium
/
Erythrocytes
/
Filtration
/
Anesthetics, Local
/
Lidocaine
Limits:
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
1973
Type:
Article
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