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Hypoparathyroidism and Subclinical Hypothyroidism with Secondary Hemochromatosis
Endocrinology and Metabolism ; : 91-95, 2014.
Article in English | WPRIM | ID: wpr-121035
ABSTRACT
Hemochromatosis is an inherited genetic disorder of iron metabolism which can also occur as a secondary result of iron-overload. It leads to organ damage such as cardiomyopathy, liver cirrhosis, hypogonadism, and diabetes. This paper discusses a case of secondary hemochromatosis associated with repeated transfusions, presenting as asymptomatic hypoparathyroidism and subclinical hypothyroidism with multiple organ involvement. The 29-year-old female, who had severe aplastic anemia, received multiple transfusions totaling approximately 1,400 units of red blood cells over 15 years. During her routine laboratory examination, hypocalcemia was detected with decreased intact parathyroid hormone and increased thyroid stimulating hormone. Serum ferritin, iron, and total iron binding capacity had increased to 27,583.03 ng/mL, 291 microg/dL, and 389 microg/dL, respectively. She had unusually bronze skin and computed tomography revealed iron deposition in the thyroid, liver, and heart. Multiorgan involvement as seen in this case is rare in hemochromatosis associated with secondary transfusions. To the best of the author's knowledge, this is the first case report in Korea of hypoparathyroidism and subclinical hypothyroidism due to iron deposition in the parathyroid and thyroid gland.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parathyroid Hormone / Skin / Thyroid Gland / Thyrotropin / Erythrocytes / Ferritins / Heart / Hemochromatosis / Hypocalcemia / Hypogonadism Limits: Adult / Female / Humans Country/Region as subject: Asia Language: English Journal: Endocrinology and Metabolism Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parathyroid Hormone / Skin / Thyroid Gland / Thyrotropin / Erythrocytes / Ferritins / Heart / Hemochromatosis / Hypocalcemia / Hypogonadism Limits: Adult / Female / Humans Country/Region as subject: Asia Language: English Journal: Endocrinology and Metabolism Year: 2014 Type: Article