A Case of Light Chain Deposition Disease Involving Kidney and Bone Marrow with Microangiopathic Hemolytic Anemia / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 384-389, 2009.
Article
in Korean
| WPRIM
| ID: wpr-12104
ABSTRACT
We report a case of light chain deposition disease in a 59-yr-old female showing deposition of monoclonal light chain in the kidney and bone marrow accompanied with a schistocytosis, the morphologic finding of microangiopathic hemolytic anemia. The immunofluorescence examination of the kidney revealed strongly stained kappa-light chain deposits on the glomerular mesangium and capillary wall, tubules, and vessel wall. The electron microscopy demonstrated electron-dense deposits on the glomerular basement membrane and mesangium. Anemia was observed with schistocytosis and Howell-Jolly body in the peripheral blood smears. The immunohistochemical examination of the bone marrow showed the presence of kappa-light chain deposits in scattered plasma cells and thickened vessel wall in the absence of a prominent plasma cell proliferation. Although an immunofixation electrophoresis failed to detect a monoclonal gammopathy, the presence of monoclonal protein could be identified by an abnormal kappa/lambda ratio on the serum free light chain analysis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraproteinemias
/
Bone Marrow
/
Immunoglobulin Light Chains
/
Glomerulonephritis
/
Anemia, Hemolytic
/
Kidney Glomerulus
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2009
Type:
Article
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