Pyridoxine induced neuropathy by subcutaneous administration in dogs
Journal of Veterinary Science
;
: 127-131, 2008.
Article
in English
| WPRIM
| ID: wpr-121051
ABSTRACT
To construct a sensory neuropathy model, excess pyridoxine (150 mg/kg s.i.d.) was injected subcutaneously in dogs over a period of 7 days. During the administrations period, the dogs experienced body weight reduction and proprioceptive loss involving the hindquarters. After pyridoxine administration was completed, electrophysiological recordings showed that the M wave remained at a normal state, but the H-reflex of the treated dogs disappeared at 7 days. The dorsal funiculus of L4 was disrupted irregularly in the axons and myelin with vacuolation. The dorsal root ganglia of L4, and sciatic and tibial nerves showed degenerative changes and vacuolation. However, the lateral and ventral funiculi of L4 showed a normal histopathologic pattern. Although this subcutaneous administration method did not cause systemic toxicity and effectively induced sensory neuropathy, this study confirmed the possibility of producing a pyridoxine-induced sensory neuropathy model in dogs with short-term administration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proprioception
/
Pyridoxine
/
Body Weight
/
Neurodegenerative Diseases
/
Disease Models, Animal
/
Electrophysiology
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2008
Type:
Article
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