Heterogeneity of white adipose tissue: molecular basis and clinical implications
Experimental & Molecular Medicine
;
: e215-2016.
Article
in English
| WPRIM
| ID: wpr-121100
ABSTRACT
Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among different anatomical depots stems from their intrinsic differences in cellular and physiological properties, including developmental origin, adipogenic and proliferative capacity, glucose and lipid metabolism, insulin sensitivity, hormonal control, thermogenic ability and vascularization. Additional factors that influence adipose tissue heterogeneity are genetic predisposition, environment, gender and age. Under obese condition, these depot-specific differences translate into specific fat distribution patterns, which are closely associated with differential cardiometabolic risks. For instance, individuals with central obesity are more susceptible to developing diabetes and cardiovascular complications, whereas those with peripheral obesity are more metabolically healthy. This review summarizes the clinical and mechanistic evidence for the depot-specific differences that give rise to different metabolic consequences, and provides therapeutic insights for targeted treatment of obesity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Population Characteristics
/
Insulin Resistance
/
Adipose Tissue
/
Genetic Predisposition to Disease
/
Lipid Metabolism
/
Adipose Tissue, White
/
Obesity, Abdominal
/
Glucose
/
Obesity
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2016
Type:
Article
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