Pancreatic regulation of glucose homeostasis
Experimental & Molecular Medicine
;
: e219-2016.
Article
in English
| WPRIM
| ID: wpr-121104
ABSTRACT
In order to ensure normal body function, the human body is dependent on a tight control of its blood glucose levels. This is accomplished by a highly sophisticated network of various hormones and neuropeptides released mainly from the brain, pancreas, liver, intestine as well as adipose and muscle tissue. Within this network, the pancreas represents a key player by secreting the blood sugar-lowering hormone insulin and its opponent glucagon. However, disturbances in the interplay of the hormones and peptides involved may lead to metabolic disorders such as type 2 diabetes mellitus (T2DM) whose prevalence, comorbidities and medical costs take on a dramatic scale. Therefore, it is of utmost importance to uncover and understand the mechanisms underlying the various interactions to improve existing anti-diabetic therapies and drugs on the one hand and to develop new therapeutic approaches on the other. This review summarizes the interplay of the pancreas with various other organs and tissues that maintain glucose homeostasis. Furthermore, anti-diabetic drugs and their impact on signaling pathways underlying the network will be discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Peptides
/
Blood Glucose
/
Neuropeptides
/
Brain
/
Glucagon
/
Comorbidity
/
Prevalence
/
Human Body
/
Diabetes Mellitus, Type 2
Type of study:
Prevalence study
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2016
Type:
Article
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