Protective effect of Hizikia fusiforme on radiation-induced damage in splenocytes / 대한수의학회지
Korean Journal of Veterinary Research
;
: 21-30, 2015.
Article
in Korean
| WPRIM
| ID: wpr-121226
ABSTRACT
The immune system is specifically sensitive to oxidative stress induced by ionizing radiation because of its rapid proliferative activity. For this reason, an instructive immune system is one of the best ways to minimize side effects, such immunodeficiency, of gamma radiation. Over the past few decades, several natural plants with antioxidant and immunomodulatory properties have been identified as adjuncts for nontoxic and successful radiotherapy. Hizikia fusiforme extract (HFE) containing plentiful dietary fiber and fucoidan is known for its instructive antioxidant capacity, immunomodulation abilities, and immune activation. In this study, we determined whether HFE protects radiosensitive immune cells from gamma radiation-induced damage. C57BL/6 mice were irradiated with gamma-ray. The effect of HFE on the ionizing radiation damage of immune cells was then evaluated with an MTT assay, 3H-thymidine incorporation assay, and PI staining. We found that HFE stimulated the proliferation of gamma-ray irradiated immune cells without cytotoxic effects. We also observed that HFE not only decreased DNA damage but also reduced gamma radiation-induced apoptosis of the immune cells. Our results suggest that HFE can protect immune cells from gamma-ray damage and may serve as an effective, non-toxic radioprotective agent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiation, Ionizing
/
Radiotherapy
/
DNA Damage
/
Dietary Fiber
/
Apoptosis
/
Oxidative Stress
/
Immunomodulation
/
Gamma Rays
/
Immune System
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Veterinary Research
Year:
2015
Type:
Article
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