A Case of Pituitary Adenoma with Simultaneous Secretion of TSH and GH
Endocrinology and Metabolism
;
: 160-165, 2011.
Article
in English
| WPRIM
| ID: wpr-121312
ABSTRACT
Thyrotropin (TSH)-secreting pituitary adenoma is a very rare disease. In one-quarter of patients suffering from this disease, the pituitary tumor secretes other anterior pituitary hormones. Herein, we report a case of pituitary adenoma with simultaneous secretion of TSH and growth hormone (GH). A 34-year-old female visitied local hospital complaining of sweating, intermittent palpitation, and weight loss of 8 kg within 1 year. The patient had undergone trans-sphenoidal surgery 3 years prior for resolution of a TSH and GH co-secreting pituitary adenoma. She had been administered somatostatin analogue prior to visiting our hospital. The patient's GH levels were suppressed to below 1 ng/mL on the 75 g oral glucose tolerance test, and her basal insulin-like growth factor-I (IGF-I) level was within normal range. Thyroid function tests demonstrated increased levels of both free thyroxine and TSH. Sella-MRI revealed pituitary adenoma at the floor of the pituitary fossa, approximately 2 cm in height. Therefore, she was diagnosed with residual TSH-secreting pituitary adenoma. The patient again underwent trans-sphenoidal surgery and entered complete remission, based on hormone levels and MRI findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Hormones, Anterior
/
Pituitary Neoplasms
/
Reference Values
/
Stress, Psychological
/
Sweat
/
Sweating
/
Thyroid Function Tests
/
Thyroxine
/
Somatostatin
/
Growth Hormone
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2011
Type:
Article
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