Allele Distribution and Frequency of Human Surfactant Protein-A2 in Korean Neonates
Journal of the Korean Pediatric Society
;
: 340-344, 2003.
Article
in Korean
| WPRIM
| ID: wpr-121369
ABSTRACT
PURPOSE:
We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy.METHODS:
Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were performed using PCR-cRFLP methods.RESULTS:
The distribution for the alleles of the SP-A2 gene in the study population was 1A, 1A0, 1A1, 1A2, 1A3, 1A5, 1A6, 1A7, 1A8, 1A9, 1A11, 1A12. The specific frequencies for the alleles of the SP- A2 gene in the study population were 1A=11.3%, 1A0=38%, 1A1=12.7%, 1A2=9.2%, 1A5=15.5%, 1A7= 2.9%, 1A8=4.9%, 1A9=2.2%, others=3.3%.CONCLUSION:
The frequency of 1A0 was higher than the other SP-A2 alleles in Korean neonates. This finding suggests that the prevalence of RDS in Korea may be low compared with other countries. However, this finding also suggests that Korean neonates have a high risk of infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
Polymerase Chain Reaction
/
Prevalence
/
Alleles
/
Gene Frequency
/
Genotype
/
Korea
Type of study:
Prevalence study
Limits:
Humans
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
2003
Type:
Article
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