A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 237-241, 2004.
Article
in Korean
| WPRIM
| ID: wpr-121425
ABSTRACT
Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia (3300/microliter with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5 (-), CD10 (-), CD19 (+), CD25 (+), CD103 (+), CD20 (+), lambda (+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Splenomegaly
/
Acid Phosphatase
/
Blood Cell Count
/
Bone Marrow
/
Infusions, Intravenous
/
B-Lymphocytes
/
Lymphocytes
/
Leukemia, Hairy Cell
/
Immunophenotyping
/
Cladribine
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Yeungnam University Journal of Medicine
Year:
2004
Type:
Article
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