Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus
Journal of Veterinary Science
;
: 137-144, 2016.
Article
in English
| WPRIM
| ID: wpr-121459
ABSTRACT
Hippocalcin participates in the maintenance of neuronal calcium homeostasis. In the present study, we examined the time-course changes of neuronal degeneration and hippocalcin protein level in the mouse hippocampus following pilocarpine-induced status epilepticus (SE). Marked neuronal degeneration was observed in the hippocampus after SE in a time-dependent manner, although neuronal degeneration differed according to the hippocampal subregions. Almost no hippocalcin immunoreactivity was detected in the pyramidal neurons of the cornu ammonis 1 (CA1) region from 6 h after SE. However, many pyramidal neurons in the CA2 region showed hippocalcin immunoreactivity until 24 h after SE. In the CA3 region, only a few hippocalcin immunoreactive cells were observed at 12 h after SE, and almost no hippocalcin immunoreactivity was observed in the pyramidal neurons from 24 h after SE. Hippocalcin immunoreactivity in the polymorphic cells of the dentate gyrus was markedly decreased from 6 h after SE. In addition, hippocalcin protein level in the hippocampus began to decrease from 6 h after SE, and was significantly decreased at 24 h and 48 h after pilocarpine-induced SE. These results indicate that marked reduction of hippocalcin level may be closely related to neuronal degeneration in the hippocampus following pilocarpine-induced SE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Status Epilepticus
/
Calcium
/
Pyramidal Cells
/
Dentate Gyrus
/
Hippocalcin
/
Hippocampus
/
Homeostasis
/
Neurons
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2016
Type:
Article
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